![]() (E) The oddball sequence contained stimuli of the same SF (0.03 cpd) that only differ in their probability and overall texture. Stimuli were presented in a pseudorandom order and had equal probability. (D) We used six different non-overlapping SF bands from 7.5E-3 to 0.24 cpd for spatial frequency tuning (many standards control). (C) To generate visual stimuli, we performed SF filtering of white noise. (B) Schematic of a 64-channel silicon probe spanning the whole cortical depth and an example of current source density (CSD) heatmap. ![]() (A) In vivo extracellular silicon probe recordings in V1 of head-fixed mice. | A visual oddball paradigm with all the stimuli containing the same low-level features but different global SF patterns and expectancy. Taken together, we demonstrated that reduced feature adaptation coexists with impaired laminar processing of oddball responses, which might contribute to altered sensory perception in FX syndrome and autism. Last, we observed altered neural dynamics in FX mice in response to stimulus omissions. Mismatch responses, on the other hand, are enriched in the superficial layers of WT animals but are present throughout lamina in FX animals. Specifically, we found that adaptation is primarily restricted to neurons with preferred oddball SF in FX compared to WT mice. Using silicon probe recordings and a novel spatial frequency (SF) oddball paradigm, we discovered that FX mice show reduced adaptation and enhanced MM responses compared to control animals. Furthermore, given that reduced habituation and sensory overload are among the hallmarks of altered sensory perception in autism, we investigated how oddball processing might be altered in a mouse model of fragile X syndrome (FX). However, it is unclear how adaptation and mismatch (MM) responses depend on the tuning properties of neurons and their laminar position. Recent animal oddball studies have advanced our understanding of circuitry underlying contextual processing in early sensory areas. Timing, but will give more accurate feel to start of run.įrom the args and kwargs arguments, respectively.Both adaptation and novelty detection are an integral part of sensory processing. Skip – how many frames to silently omit initially during T1 Sync – character used as flag for sync timing, default=’5’ Volumes – number of 3D volumes to obtain in a given scanning run Recommend: TR=1.000 or higher and less than 100% CPU. Adds an arbitrary ‘sync’ character to the keyīuffer, with sub-millisecond precision (less precise if CPU is maxed). SyncGenerator ( TR = 1.0, TA = 1.0, volumes = 10, sync = '5', skip = 0, sound = False, ** kwargs ) ¶Ĭlass for a character-emitting metronome threadĪim: Allow testing of temporal robustness of fMRI scripts by emulatingĪ hardware sync pulse. Target argument, if any, with sequential and keyword arguments takenįrom the args and kwargs arguments, respectively. Invokes the callable object passed to the object’s constructor as the You may override this method in a subclass. Method representing the thread’s activity. Simulate a user pressing a key at a specific time (relative toĪuthor: Jeremy Gray Idea: Mike MacAskill run ( ) ¶ Given a list of response tuples (time, key), the thread will ResponseEmulator ( simResponses = None ) ¶Ĭlass to allow simulation of a user’s keyboard responses Psychopy-mri-emulator extension into the current environment. These are optional components that can be obtained by installing the Limitations: pyglet only keyboard events only. Idea: Run or debug an experiment script using exactly the same code, i.e., forīoth testing and online data acquisition. Launch an fMRI experiment: Test or Scan ¶
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